Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
Both Bmi and weight was in fact synchronised which have BMD, and BMC indicators plus the strongest Pearson’s correlation coefficients was indeed receive ranging from weight and you can BMC as a whole cool and you can trochanter countries and you will the weakest of those was in fact anywhere between Body mass index and femoral neck BMC. The brand new correlations anywhere between decades and you will BMD and you may BMC indications was negative (Table cuatro).
The age-adjusted proportion of BMD and you may BMC version explained from the Body mass index and you will pounds is shown into the Dining table 5. Pounds had a tendency to inform you deeper variations in BMD and you may BMC shipments whatsoever the brand new read skeletal sites compared to Bmi. It was mirrored from the steeper hill (?) of your own respective linear regression traces. The best difference between BMD and BMC shipping checked during the trochanter BMC accompanied by lumbar BMC having weight. Weight is an important predictor from BMD and you may BMC adaptation inside the older Iranian boys.
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator sitios de citas profesionales mÃ©dicos for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
This new mechanisms wherein adipose tissue exerts positive effects into the BMD updates are not entirely clear. Brand new putative system significance out-of fatty tissue getting skeletal stability most likely lives in the brand new role of numerous adipokines within the limbs remodeling as a result of affect both development and you can resorption. Recently, bone might have been experienced an enthusiastic endocrine organ impacting pounds handle and sugar homoeostasis through the methods off bones-derived situations for example osteocalcin and you will osteopontin [23, 34–36]. The latest putative crosstalk ranging from fat therefore the bones constitutes an excellent homoeostatic opinions program in which adipokines and you can molecules secreted by osteoblasts and you can osteoclasts depict the link out-of an active bone-adipose axis [34–36]. Carrying excess fat is also for the BMD by the transformation from androgen so you’re able to the hormone estrogen , and this improves bone bulk in individuals [38, 39] and you can holds healthy plasma quantities of insulin and managing issues along with insulin-instance progress grounds-step one, leptin, and you may adiponectin . On top of that, obesity will bring padding on the stylish in case there are good fall . However, the newest systems by which many of these situations occur are nevertheless unsure.